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PRODUCT
Sterile Connectors for use in Pharma
Sterile Connectors for use in Pharma

Sterile quick connector

    The benefits of disposable systems can be seen throughout the entire biopharmaceutical manufacturing process, from filter integrity testing to terminal filling operations. Whether they are used in upstream or downstream processes, sterile assurance is crucial.


Product description

Aseptic connection
Disposable technology: sterile connection suitable for sterile medium delivery.
The benefits of disposable systems can be seen throughout the entire biopharmaceutical manufacturing process, but sterile assurance is crucial whether you are in an upstream or downstream process. CPC's innovative connection technology enables manufacturers to quickly and easily perform aseptic connections between disposable bag systems, tube components, and/or stainless steel process equipment.
Steam-Thru ® The connector can quickly and conveniently connect biopharmaceutical process equipment, disposable sterile bags, and tube components in a sterile manner. You can safely transport media without worrying about cleaning and validation issues related to reusable components.
AseptiQuik @ connector can achieve sterile medium transfer between tube components and bag components even in a bacterial environment. The durable design of the joint ensures reliable performance, without the need for clamps, fixtures, and welding machines, and can be connected without using laminar flow purification hoods.

Aseptic disconnection
Disposable technology: sterile disconnection suitable for sterile medium delivery.
The benefits of disposable systems can be seen throughout the entire biopharmaceutical manufacturing process, from filter integrity testing to terminal filling operations. Whether they are used in upstream or downstream processes, sterile assurance is crucial.
Nowadays, CPC's HFC39 quick plug connector allows process engineers to safely disconnect pipelines and process lines without the risk of contamination. The automatic shut-off valve can aseptically close the flow channel, protecting valuable media without the need for pipeline clamps and welding machines. These lightweight connectors can be easily integrated with disposable components and meet all requirements for animal free ingredients (ADCF).

Steam-Thru ® joint
Disposable technology: Steam Thru.
CPC's patented Steam Thru ® The joint technology creates a sterile connection between pre sterilized bag systems or tube components and stainless steel process equipment. The innovative three port design of this product eliminates "dead corners" and allows steam to pass through the joint directly into the stainless steel equipment, ensuring maximum sterility.
The launch of CPC Steam Thru II further expands sterile assurance; Steam Thru II can provide "steam on" and "steam off" functions, enabling sterile connection and disconnection without the need for laminar flow purification hoods. This reduces the possibility of microbial contamination in the process flow channel and also reduces environmental pollution within the facility.
CPC's Steam Thru ® The product line includes several valve and end options, allowing you to flexibly meet today's installation and flow requirements. The connector is connected to a disposable bag system or pipeline, and then pre sterilized using gamma irradiation up to 50 kGy, or sterilized with high-pressure steam at a temperature of up to 129 °C for 60 minutes, depending on the product configuration.
For installation on processing equipment, engineers can specify the connection to the hygiene end of the middle port, which is either three-quarters "or 1- half". The T-shaped clamp is used to secure the middle sanitary end to the equipment and the lower sanitary end to the steam trap. After connection, these two lower ports can achieve a true SIP steam penetration sterilization program, thereby avoiding potential "dead corners" that may trap pollutants. With the help of Steam Thru ® II, You can perform a SIP cycle with a temperature of up to 135 °C or a pressure of 35 PSI, lasting up to 60 minutes, to allow steam to enter the equipment through the joint. The effectiveness of the "steam on" cycle was confirmed through a bacterial challenge using thermophilic Bacillus subtilis conducted by the Biotechnology Research Center at the University of Minnesota.
After the SIP cycle is completed, the operator only needs to press the thumb lock to switch the valve from the steam position to the flow position. This creates a sterile flow channel between stainless steel equipment and disposable systems, enabling the delivery of sterile fluids. Steam-Thru ® One major advantage of the II valve design is that its Cv value can reach 8.2, which translates to a flow rate of 43.9 L/min (at a pressure of 2 PSI), making it highly suitable for high-capacity applications.
After the fluid delivery is completed, press the thumb lock again to return the valve to the steam position, in order to perform the second SIP or "steam off" cycle. This can eliminate all remaining biological residues between process equipment and disposable systems, thereby greatly reducing the possibility of environmental pollution during disconnection.
In addition to completing bacterial challenge tests on the "steam on" cycle, bacterial challenge tests were also conducted on the "steam off" cycle after medium delivery. Northview Labs conducted bacterial invasion testing using defective short wave bacteria to verify post sterilization sealing performance. We have also completed other performance tests including helium/steam leakage, tensile testing, and blasting to ensure design and process integrity. Steam-Thru ® II contains non animal derived USP Level 6 certified polysulfone and platinum sulfide silicone sealing materials, which have undergone biocompatibility testing.

Performance advantages

Ergonomic thumb lock, easy to operate even with gloves on
USP VI level certification, compliant with biological adaptability requirements
High pressure steam sterilization, Et0, Light waves or gamma rays
The joint is sturdy and affordable, suitable for one-time use
The undifferentiated hook eliminates potential leakage paths
Does not contain BSE/TSE materials and meets ADCF requirements

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